Ergopharm 6-OXO Review


Note: 6-OXO has been banned and discontinued

By Bodybuilding Science

Background

I am very rarely impressed by the credentials and/or effects of a commercially available supplement. However, 6-OXO is one of those few products that made my list. Not only was I able to find a published study that demonstrated the main chemical is 6-OXO was able to significantly increase the amount of free testosterone and reduce the amount of a certain estrogen in the body, but when I tried it, I actually noticed a significant difference. Though it is marketed as an estrogen reducer, it is actually far more effective as a testosterone booster.

I will explain the chemistry behind the claims later in this article. And the best part is that it contains no synthetic testosterone or testosterone prohormones, so your body doesn’t shut down its own testosterone production (i.e. testicular shrinkage). On the contrary, it actually works to boost your bodies natural production of testosterone! Let’s get into the nuts and bolts to figure out how it works.

The main component of 6-OXO is called 4-Etioallocholen-3,6,17-Trione. This is standard nomenclature for this chemical, but it is also known as 4-Androstene-3,6,17-trione. This chemical is what is known as an aromatase inhibitor. But what does any of this mean?

What is Aromatase?

Aromatase is an enzyme that converts androgens (namely testosterone) into estrogen. 4-Androstene-3,6,17-trione inhibits this enzyme and prevents the conversion of testosterone in to estrogen. By doing this, testosterone levels are raised (because less testosterone is broken down) and estrogen levels are lowered (because less extra testosterone is converted to estrogen). This is the reasons many steroid users turn to 6-OXO during and after cycles. Excess testosterone is normally converted to estrogen and leads to the telltale signs of steroid abuse (breast tissue formation, elevated body fat, etc). By using this compound, the excess testosterone is unable to be converted, and thus does not contribute to these side effects.

How does 6-OXO work?

The 4-Androstene-3,6,17-trione disables the Aromatase enzyme. The chemical reaction is classified as a “suicide inhibition”. What this really means is that one molecule of 4-Androstene-3,6,17-trione binds to one molecule of Aromatase permanently. The Aromatase molecule is not destroyed or broken into pieces, but it is neutralized by the 4-Androstene-3,6,17-trione. While these molecules are bonded together, Aromatase cannot interact with testosterone and convert it to estrogen, and is eventually degraded by other enzymes or eliminated through urine.

What effects can I expect?

The intensity of effects depends on your dosage, of course, but these effects are typically associated with high testosterone and low estrogen levels:
Low body fat levels
Counteraction of gynomastia (man boobs)
A “hard” defined look
Counteraction of testicular shutdown (shrinkage)
Enhanced muscle growth and recovery
Increased sexual drive
Increased aggression (mood or behavior)

What research has been done?

The company that sells this product claims that “an independent study” showed very impressive numbers, but the research (as far as I know) is not publicly available. There is however several studies on 4-Androstene-3,6,17-trione on its use against breast cancers due to its estrogen lowering ability, which gives it much more creditability in my book. Of course the dosages are much lower in these trials, so its still up in the air as far as safety is concerned. Several studies looking at this compound are noted at the end of this article.

How safe is it?

Beats me… Probably not the answer you were looking for. Because this is a relatively new compound, no long term studies could have been done. While it does not appear to have any acutely toxic effects, long term use of this may have health risks, we just can’t know for sure. Ergopharm recommends taking this product in cycles for no longer than six weeks with at least six weeks off in between cycles. This is a very potent product and it can have a serious effect on your bodies hormonal chemistry, so don’t use this product haphazardly. I would recommend getting your blood levels checked on a weekly basis by a physician during and after the use of this product if you want to be extra careful.

Does it work?

Yes. That’s the one thing we’re sure of. It will raise your testosterone and lower your estrogen. Use it carefully, use it wisely, and you’ll have great results. Like most in demand supplements, this stuff is quite expensive. If you’re smart, you’ll buy it online. The cheapest place I found when I purchased mine was here (you can save even more money per pill if you buy the large bottle). If you can find a better deal, let us know about it and we’ll post it here. Good luck, get huge.

Works Cited

endo.endojournals.org/cgi/content/abstract/108/4/1597
www.ncbi.nlm.nih.gov/sites/entire?cmd=Retrieve&db=PubMed&list_uids=2214767&dopt=Citation
www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=3657156&dopt=Citation
en.wikipedia.org/wiki/4-Androstene-3,6,17-trione

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